2BAct

MedChem Express

2BAct [2143542-28-1]

9

2143542-28-1

Research Use Only

99.31

C19H16ClF3N4O3

440.80

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC 50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) [1] .

O=C(C(C=N1)=NC=C1C(F)F)NC(C2)(C3)CC23NC(COC(C=C4)=CC(F)=C4Cl)=O

2°C to 8°C

12352200