3-Azido-2,3-dideoxy-CTP

MedChem Express

3-Azido-2,3-dideoxy-CTP

999

Research Use Only

C9H15N6O12P3

492.17

3-Azido-2,3-dideoxy-CTP (AZddCTP) is a cytidine analog containing a 3-azido group. As a chain terminator, 3-Azido-2,3-dideoxy-CTP can be incorporated into the nascent DNA chain by HIV reverse transcriptase. 3-Azido-2,3-dideoxy-CTP terminates DNA synthesis due to the lack of a 3-hydroxyl group, thereby inhibiting viral replication. 3-Azido-2,3-dideoxy-CTP has IC50 values of 15.6 microM and 160.8 microM for WT HIV and AZTR HIV. 3-Azido-2,3-dideoxy-CTP has antiviral activity[1].

O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)C[C@@H]1N=[N+]=[N-]

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