3-Azido-2,3-dideoxyuridine

MedChem Express

3-Azido-2,3-dideoxyuridine [84472-85-5]

10

84472-85-5

Research Use Only

99.11

C9H11N5O4

253.21

3-Azido-2,3-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3-Azido-2,3-dideoxyuridine is a potent inhibitor of human immunodeficiency virus ( HIV ) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC) [1] [2] [3] . 3-Azido-2,3-dideoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

OC[C@H]([C@@H](N=[N+]=[N-])C1)O[C@H]1N(C=C2)C(NC2=O)=O

-20°C

12352200