3-Azido-3-deoxy-2-thiouridine [2305416-00-4]
HY-152353
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product Name3-Azido-3-deoxy-2-thiouridine [2305416-00-4]
- Delivery Days Customer10
- CAS Number2305416-00-4
- CertificationResearch Use Only
- Molecular FormulaC9H11N5O4S
- Molecular Weight285.28
- Scientific Description3-Azido-3-deoxy-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-Azido-3-deoxy-2-thiouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- SMILESO=C(N1)C=CN([C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])[C@H]2O)C1=S
- UNSPSC41115811