3-Azido-3-deoxy-5-fluoro-beta-L-uridine [2095417-40-4]

MedChem Express

3-Azido-3-deoxy-5-fluoro-beta-L-uridine [2095417-40-4]

10

2095417-40-4

Research Use Only

C9H10FN5O5

287.20

3-Azido-3-deoxy-5-fluoro-beta-L-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-Azido-3-deoxy-5-fluoro-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O[C@H]1[C@@H](N=[N+]=[N-])[C@H](CO)O[C@@H]1N2C=C(F)C(NC2=O)=O

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