3-Azido-3-deoxy-5-trifluoromethyluridine [2095417-62-0]

MedChem Express

3-Azido-3-deoxy-5-trifluoromethyluridine [2095417-62-0]

10

2095417-62-0

Research Use Only

C10H10F3N5O5

337.21

3-Azido-3-deoxy-5-trifluoromethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-Azido-3-deoxy-5-trifluoromethyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N(C(N2)=O)C=C(C(F)(F)F)C2=O)O1

41115811