3-Azido-3-deoxy-6-azauridine

MedChem Express

3-Azido-3-deoxy-6-azauridine

10

Research Use Only

C8H10N6O5

270.20

3-Azido-3-deoxy-6-azauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-Azido-3-deoxy-6-azauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O=C(C=N1)NC(N1[C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])[C@H]2O)=O

41106300