3-Azido-3-deoxy-N6,N6-dimethyladenosine [384334-64-9]

MedChem Express

3-Azido-3-deoxy-N6,N6-dimethyladenosine [384334-64-9]

10

384334-64-9

Research Use Only

C12H16N8O3

320.31

3-Azido-3-deoxy-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-Azido-3-deoxy-N6,N6-dimethyladenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O[C@@H]1[C@H](N=[N+]=[N-])[C@@H](CO)O[C@H]1N(C=N2)C3=C2C(N(C)C)=NC=N3

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