3-Azido-3-deoxyadenosine [58699-62-0]

MedChem Express

3-Azido-3-deoxyadenosine [58699-62-0]

10

58699-62-0

Research Use Only

98.44

C10H12N8O3

292.25

3-Azido-3-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-Azido-3-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1N=[N+]=[N-]

-20°C,2°C to 8°C

12131703