3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles

MedChem Express

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles

5

Research Use Only

99.84

C11H6F3N3OS

285.25

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 microM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model[1][2].

N#CC1=C(NC2=CC=CC=C2C(F)(F)F)SNC1=O

-20°C,2°C to 8°C

12352200