3-Hydroxyflunitrazepam [67739-71-3]
HY-121057
CAS Number67739-71-3
Product group Chemicals
Molecular Weight329.28
Overview
- SupplierMedChem Express
- Product Name3-Hydroxyflunitrazepam [67739-71-3]
- Delivery Days Customer5
- CAS Number67739-71-3
- CertificationResearch Use Only
- Molecular FormulaC16H12FN3O4
- Molecular Weight329.28
- Scientific Description3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 microM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (HY-B0105) (IC50 = 0.11 microM) and Ritonavir (HY-90001) (IC50 = 0.041 microM), indicating a strong dependence on CYP3A4 activity and potential drug interactions[1].
- SMILESO=C1C(O)N=C(C2=CC=CC=C2F)C3=CC([N+]([O-])=O)=CC=C3N1C
- UNSPSC12352200