3-Methyluridine [2140-69-4]

MedChem Express

3-Methyluridine [2140-69-4]

10

2140-69-4

Research Use Only

99.05

C10H14N2O6

258.23

3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance[1][2][3].

O[C@H]1[C@@H](O)[C@H](N(C(N2C)=O)C=CC2=O)O[C@@H]1CO

2°C to 8°C

12352200