3-O-(2-Azidoethyl)adenosine

MedChem Express

3-O-(2-Azidoethyl)adenosine

10

Research Use Only

C12H16N8O4

336.31

3-O-(2-Azidoethyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3-O-(2-Azidoethyl)adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

OC[C@@H]1[C@@H](OCCN=[N+]=[N-])[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1

41115811