3,4,7-Trihydroxyflavone [2150-11-0]

MedChem Express

3,4,7-Trihydroxyflavone [2150-11-0]

5

2150-11-0

Research Use Only

98.0

C15H10O5

270.24

3,4,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 microM) and COX-1 (IC50 = 36.37 microM). 3,4,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-alpha. 3,4,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3,4,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3,4,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3,4,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice[1][2][3][4][5][6][7][8][9].

O=C1C2=CC=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1

RT

12352200