(3S)-hydroxy Quinidine [53467-23-5]

TargetMol Chemicals

(3S)-hydroxy Quinidine [53467-23-5]

44

53467-23-5

Chemical

Research Use Only

(3S)-hydroxy Quinidine

C20H24N2O3

340.42

(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.

3 years

[C@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@@]3([N@@]4C[C@@](C=C)(O)[C@](C3)(CC4)[H])[H]

-20°C

12352200