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(3S)-Tanzisertib (hydrochloride)

HY-15495B
MedChem Express
Molecular Weight484.90
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (3S)-Tanzisertib (hydrochloride)
  • Delivery Days Customer
    999
  • Certification
    Research Use Only
  • Molecular Formula
    C21H24ClF3N6O2
  • Molecular Weight
    484.90
  • Scientific Description
    (3S)-Tanzisertib (hydrochloride) ((3S)-CC-930 (hydrochloride)) is an orally active JNK inhibitor (IC50 values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively). (3S)-Tanzisertib (hydrochloride) selectively inhibits ERK1, p38alpha, and EGFR (IC50 = 0.48, 3.4, and 0.38 microM, respectively). (3S)-Tanzisertib (hydrochloride) inhibits LPS-induced TNFalpha production in an acute rat PK-PD model. (3S)-Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research[1].
  • SMILES
    OC(CC1)CCC1NC2=NC=C3C(N([C@H]4CCOC4)C(NC5=C(C=C(C=C5F)F)F)=N3)=N2.Cl
  • UNSPSC
    12352200

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