(3S,5S,6R)-Navtemadlin

MedChem Express

(3S,5S,6R)-Navtemadlin [2459946-14-4]

14

2459946-14-4

Research Use Only

97.01

C28H35Cl2NO5S

568.55

(3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC 50 of 0.6 nM. Navtemadlin binds to MDM2 with a K d of 0.045 nM [1] [2] .

CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O

-20°C,2°C to 8°C

12352200