4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid [124243-00-1]

MedChem Express

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid [124243-00-1]

5

124243-00-1

Research Use Only

97.67

C25H24O7S2

500.58

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to staple two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.

O=C(C1=CC=C(C=C1)C(O)=O)C(CS(=O)(C2=CC=C(C=C2)C)=O)CS(=O)(C3=CC=C(C=C3)C)=O

RT

12352200