4-Azido-3-O-benzoyl-5-O-(m-chlorobenzoyl)-2-deoxy-2-fluoro-beta-D-arabinouridine [1333126-30-9]

MedChem Express

4-Azido-3-O-benzoyl-5-O-(m-chlorobenzoyl)-2-deoxy-2-fluoro-beta-D-arabinouridine [1333126-30-9]

10

1333126-30-9

Research Use Only

C23H17ClFN5O7

529.86

4-Azido-3-O-benzoyl-5-O-(m-chlorobenzoyl)-2-deoxy-2-fluoro-beta-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 4-Azido-3-O-benzoyl-5-O-(m-chlorobenzoyl)-2-deoxy-2-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O=C(C1=CC=CC(Cl)=C1)OC[C@]2(N=[N+]=[N-])[C@@H](OC(C3=CC=CC=C3)=O)[C@H](F)[C@H](N4C(NC(C=C4)=O)=O)O2

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