4-Chloropyridine [626-61-9]
HY-W093017
CAS Number626-61-9
Product group Chemicals
Molecular Weight113.54
Overview
- SupplierMedChem Express
- Product Name4-Chloropyridine [626-61-9]
- Delivery Days Customer5
- CAS Number626-61-9
- CertificationResearch Use Only
- Molecular FormulaC5H4ClN
- Molecular Weight113.54
- Scientific Description4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMTs activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes [1].
- SMILESClC1=CC=NC=C1
- UNSPSC12352200