4-DTMP [21253-58-7]

MedChem Express

4-DTMP [21253-58-7]

14

21253-58-7

Research Use Only

97.33

C13H16N4O3

276.30

4 -DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 -DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 -DTMP has potential inhibition of E.coli[1].

OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC

-20°C,2°C to 8°C

12352200