4-Hydroxyderricin

MedChem Express

4-Hydroxyderricin [55912-03-3]

10

55912-03-3

Research Use Only

99.97

C21H22O4

338.40

4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 microM. 4-Hydroxyderricin also mildly inhibits dopamine beta (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation[1]. 4-Hydroxyderricin is promising for research of inflammatory diseases[1][2][3][4][5].

O=C(C1=CC=C(OC)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2

2°C to 8°C

12352200