4-Methoxy-S-trityl-L-cysteinol [1338701-15-7]

MedChem Express

4-Methoxy-S-trityl-L-cysteinol [1338701-15-7]

5

1338701-15-7

Research Use Only

C23H25NO2S

379.52

4-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 microM, showing stronger inhibitory potency than the parent molecule and monastrol.

OC[C@@H](N)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC

12352200