4-Methylumbelliferyl alpha-D-glucopyranoside [17833-43-1]

Chemodex

4-Methylumbelliferyl alpha-D-glucopyranoside [17833-43-1]

2

17833-43-1

Research Use Only

>99%

C16H18O8

338.31

4-Methylumbelliferyl-alpha-D-glucopyranoside is a non-fluorescent but sensitive fluorogenic substrate for alpha-glucosidase yielding a blue fluorescent solution. 4-Methylumbelliferyl-alpha-D-glucopyranoside is cleaved by alpha-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-alpha-D-glucopyranoside has been used to quantify alpha-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme and and fundamental research into carbohydrate-metabolizing enzyme function. Spectral Data: lambdaEx/lambdaEm= 360/450 nm (cleaved product, pH-dependent). - Chemical. CAS: 17833-43-1. Formula: C16H18O8. MW: BD10218. 4-Methylumbelliferyl-alpha-D-glucopyranoside is a non-fluorescent but sensitive fluorogenic substrate for alpha-glucosidase yielding a blue fluorescent solution. 4-Methylumbelliferyl-alpha-D-glucopyranoside is cleaved by alpha-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-alpha-D-glucopyranoside has been used to quantify alpha-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme and and fundamental research into carbohydrate-metabolizing enzyme function. Spectral Data: lambdaEx/lambdaEm= 360/450 nm (cleaved product, pH-dependent).

CC=1C=2C(=CC(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1

-20°C

12162000