4-Methylumbelliferyl-alpha-D-Glucopyranoside [17833-43-1]

TargetMol Chemicals

4-Methylumbelliferyl-alpha-D-Glucopyranoside [17833-43-1]

16

17833-43-1

Chemical

Research Use Only

4-Methylumbelliferyl-alfa-D-Glucopyranoside

C16H18O8

338.312

4-Methylumbelliferyl-alpha-D-glucopyranoside serves as a fluorogenic substrate for alpha-glucosidase, used in enzymatic assays. This compound undergoes cleavage by alpha-glucosidase, releasing 4-methylumbelliferyl (4-MU), a compound whose fluorescence intensity varies with pH. Specifically, 4-MU exhibits excitation peaks at 320 nm and 360 nm in acidic (pH 1.97-6.72) and alkaline environments (pH 7.12-10.3), respectively, and its emission peak ranges between 445 nm and 455 nm, with brightness increasing as the pH drops. Utilizing these properties, 4-Methylumbelliferyl-alpha-D-glucopyranoside has been effectively applied in the measurement of alpha-glucosidase activity within infant blood spot samples, acting as a diagnostic marker for Fabry and Pompe diseases. These illnesses are types of lysosomal storage disorders caused by alpha-glucosidase enzyme deficiency.

3 years

Cc1cc(=O)oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

-20°C

12352200