4-Methylumbelliferyl-alpha-D-Glucopyranoside [17833-43-1]

MedChem Express

4-Methylumbelliferyl-alpha-D-Glucopyranoside [17833-43-1]

5

17833-43-1

Research Use Only

99.99

C16H18O8

338.31

4-Methylumbelliferyl-alpha-D-Glucopyranoside (4-Methylumbelliferyl-alpha-D-Glucose) is a fluorescent substrate for alpha-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-alpha-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-alpha-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify alpha-glucosidase activity in infant blood spot samples.

O=C1C=C(C)C2=CC=C(O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2O1

2°C to 8°C

12162000