4-Methylumbelliferyl-alpha-L-Iduronide (free acid) [66966-09-4]

TargetMol Chemicals

4-Methylumbelliferyl-alpha-L-Iduronide (free acid) [66966-09-4]

44

66966-09-4

Research Use Only

4-Methylumbelliferyl-alfa-L-Iduronide (free acid)

C16H16O9

352.295

4-Methylumbelliferyl-alpha-L-iduronide (free acid) is a fluorogenic substrate for alpha-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-alpha-L-iduronide is cleaved by alpha-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of alpha-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.

3 years

Cc1cc(=O)oc2cc(O[C@@H]3O[C@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)ccc12

-20°C

12352200