4-N3Pfp-NHS ester [126695-58-7]
HY-126525
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product Name4-N3Pfp-NHS ester [126695-58-7]
- Delivery Days Customer10
- CAS Number126695-58-7
- CertificationResearch Use Only
- Molecular FormulaC11H4F4N4O4
- Molecular Weight332.17
- Scientific Description4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 4-N3Pfp-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- SMILESO=C(ON1C(CCC1=O)=O)C2=C(F)C(F)=C(N=[N+]=[N-])C(F)=C2F
- UNSPSC41115800