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4-trans-Hydroxy-glibenclamide

HY-117160
MedChem Express
CAS Number23155-00-2
DownloadMSDS
Product group Chemicals
Molecular Weight510.00
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Overview

  • Supplier
    MedChem Express
  • Product Name
    4-trans-Hydroxy-glibenclamide [23155-00-2]
  • Delivery Days Customer
    5
  • CAS Number
    23155-00-2
  • Certification
    Research Use Only
  • Molecular Formula
    C23H28ClN3O6S
  • Molecular Weight
    510.00
  • Scientific Description
    rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC 50 values of 0.95 and 100 nM, respectively.
  • SMILES
    O=C(NCCC1=CC=C(S(=O)(NC(N[C@H]2CC[C@H](O)CC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC
  • UNSPSC
    12352200

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Chemical Structure
Product group Chemicals
Chemodex
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Estimated Purity>97%
Molecular Weight510
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