5-Benzyloxygramine [1453-97-0]

TargetMol Chemicals

5-Benzyloxygramine [1453-97-0]

4

1453-97-0

Chemical

Research Use Only

5-Benzyloxygramine

0.9633

C18H20N2O

280.36

5-Benzyloxygramine is an N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. It stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization, which was further confirmed in cell studies[1]. [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.

3 years

CN(C)Cc1c[nH]c2ccc(OCc3ccccc3)cc12

-20°C

12352200