5-Dibenzylcyclooctyne-2-deoxyuridine (5-DBCO-dU), 5-Dibenzylcyclooctyne-dU

Jena Bioscience

5-Dibenzylcyclooctyne-2-deoxyuridine (5-DBCO-dU), 5-Dibenzylcyclooctyne-dU

5

Research Use Only

≥95%

C31H28N4O7 (free acid)

568.58 g/mol (free acid)

5-DBCO-dU (5-Dibenzylcyclooctyne-2-deoxyuridine) can potentially be used as a replacement for BrdU (5-Bromo-2-deoxyuridine) or the copper-catalyst requiring 5-EdU (5-Ethynyl-2-deoxyuridine) to measure de novo DNA synthesis in proliferating cells. 5-DBCO-dU is cell permeable and may incorporate into replicating DNA instead of its natural analog thymidine. The resulting DBCO-functionalized DNA can subsequently be detected via Cu(I)-free Click Chemistry that offers the choice tointroduce a Biotin group for subsequent purification tasks (via Azides of Biotin)introduce a fluorescent group for subsequent microscopic imaging (via Azides of fluorescent dyes).

c1(=O)[nH]c(=O)n(cc1C#CCNC(=O)CCC(=O)N1Cc2c(C#Cc3c1cccc3)cccc2)[C@H]1C[C@H](O)[C@H](O1)CO

-20°C

12352200