5-Hydroxymethylcytosine [1123-95-1]

MedChem Express

5-Hydroxymethylcytosine [1123-95-1]

5

1123-95-1

Research Use Only

99.91

C5H7N3O2

141.13

5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimers, Parkinsons) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes)[1][2].

O=C1N=CC(CO)=C(N1)N

-20°C,2°C to 8°C

12352200