5-LOX/sEH-IN-1

MedChem Express

5-LOX/sEH-IN-1

5

Research Use Only

C18H15N7O

345.36

5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 microM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 microM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects[1].

N#CC1=C(N)N2C(NC1C3=CC=C(OC)C=C3)=NN=C2C4=CC=CN=C4

12352200