5-(N,N-Hexamethylene)-amiloride [1428-95-1]

MedChem Express

5-(N,N-Hexamethylene)-amiloride [1428-95-1]

5

1428-95-1

Research Use Only

98%

C12H18ClN7O

311.77

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 microM and 1.34 microM, respectively.

O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N

2°C to 8°C,-20°C,-80°C

12352200