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5-(N,N-Hexamethylene)-amiloride [1428-95-1]

HY-128067
MedChem Express
CAS Number1428-95-1
Product group Chemicals
Estimated Purity98%
Molecular Weight311.77
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    5-(N,N-Hexamethylene)-amiloride [1428-95-1]
  • Delivery Days Customer
    10
  • CAS Number
    1428-95-1
  • Estimated Purity
    98%
  • Molecular Formula
    C12H18ClN7O
  • Molecular Weight
    311.77
  • Scientific Description
    5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 microM and 1.34 microM, respectively.
  • SMILES
    O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200