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5-ODMT cEt N-Bz A Phosphoramidite (Amidite) [1197033-19-4]

HY-148503
MedChem Express
Product group Molecular Biology
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Overview

  • Supplier
    MedChem Express
  • Product Name
    5-ODMT cEt N-Bz A Phosphoramidite (Amidite) [1197033-19-4]
  • Delivery Days Customer
    10
  • CAS Number
    1197033-19-4
  • Certification
    Research Use Only
  • Estimated Purity
    98.55
  • Molecular Formula
    C49H54N7O8P
  • Molecular Weight
    899.97
  • Scientific Description
    5-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2,4-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment[1][2].
  • SMILES
    COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@]45[C@H]([C@](O[C@H]5C)([H])[C@H](N6C7=NC=NC(NC(C8=CC=CC=C8)=O)=C7N=C6)O4)OP(OCCC#N)N(C(C)C)C(C)C
  • Storage Instruction
    -20°C
  • UNSPSC
    41115811