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5-Vinyl-uridine (5-VU), 5-Ethenyl-uridine [55520-64-4]

Research Use Only
CLK-049-10
Jena Bioscience
CAS Number55520-64-4
Product group Chemicals
Estimated Purity≥98%
Molecular Weight270.24 g/mol
€ 193,00
10 mg
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Overview

  • Supplier
    Jena Bioscience
  • Product Name
    5-Vinyl-uridine (5-VU), 5-Ethenyl-uridine [55520-64-4]
  • Delivery Days Customer
    5
  • CAS Number
    55520-64-4
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Molecular Formula
    C11H14N2O6
  • Molecular Weight
    270.24 g/mol
  • Scientific Description
    5-VU (5-Vinyl-uridine) can potentially be used as a replacement for BrU (5-Bromo-uridine) or the copper-catalyst requiring 5-EU (5-Ethynyl-uridine) to measure de novo RNA synthesis in proliferating cells. 5-VU is cell permeable and might incorporate into nascent RNA instead of its natural analog uridine. This assumption is based on the previously demonstrated suitability of 5-VdU (5-Vinyl-2-deoxyuridine) for DNA synthesis monitoring[1]. The resulting vinyl-functionalized RNA could subsequently be detected via Cu(I)-free Alkene-Tetrazine Ligation that offers the choice to introduce a Biotin group (via Tetrazines of Biotin) for subsequent purification tasks or a fluorescent group (via Tetrazines of fluorescent dyes) for subsequent microscopic imaging.
  • SMILES
    n1(cc(c(=O)[nH]c1=O)C=C)[C@H]1[C@@H]([C@@H]([C@H](O1)CO)O)O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200