53BP1 antibody
GTX70310
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetTP53BP1
Overview
- SupplierGeneTex
- Product Name53BP1 antibody - KO/KD Validated
- Delivery Days Customer9
- Application Supplier NoteSuggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.94 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID7158
- Target nameTP53BP1
- Target descriptiontumor protein p53 binding protein 1
- Target synonyms53BP1; p202; p53-binding protein 1; p53BP1; TDRD30; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor suppressor p53-binding protein 1
- HostRabbit
- IsotypeIgG
- Protein IDQ12888
- Protein NameTP53-binding protein 1
- Scientific DescriptionP53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. McMahon KA et al., 2021 Jun 18, ElifeRead more