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53BP1 antibody

GTX70310
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetTP53BP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    53BP1 antibody - KO/KD Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    Suggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.94 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7158
  • Target name
    TP53BP1
  • Target description
    tumor protein p53 binding protein 1
  • Target synonyms
    53BP1; p202; p53-binding protein 1; p53BP1; TDRD30; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor suppressor p53-binding protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ12888
  • Protein Name
    TP53-binding protein 1
  • Scientific Description
    P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. McMahon KA et al., 2021 Jun 18, Elife
    Read more

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