5alpha-Androstan-3beta-ol

Biorbyt

5alpha-Androstan-3beta-ol

10

1224-92-6

Research Use Only

98.00%

C19H32O

276.46

5alpha-Androstan-3beta-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 microM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 microM. It selectively inhibits the hydroxylase activities of 16alpha- and 6beta-hydroxylase over 16beta- or 7alpha-hydroxylase, with IC50 values of 70 and 110 microM, compared to > 150 microM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.

C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)CCC4)[H])(CC[C@]1(C[C@@H](O)CC2)[H])[H])[H]

-20°C

12352200