6-Aminonicotinamide

MedChem Express

6-Aminonicotinamide [329-89-5]

10

329-89-5

Research Use Only

99.95

C6H7N3O

137.142

6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP + -dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor ( K i =0.46 microM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells [1] [2] [3] [4] .

NC1=CC=C(C(N)=O)C=N1

2°C to 8°C

12352200