6-Aminophenanthridine [832-68-8]

TargetMol Chemicals

6-Aminophenanthridine [832-68-8]

10

832-68-8

Chemical

Research Use Only

6-Aminophenanthridine

C13H10N2

194.23

6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the alpha2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 microM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 microM and in adults following dietary administration of 1-3 mM doses. 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.

3 years

NC1=C2C(=C3C(=N1)C=CC=C3)C=CC=C2

-20°C

12352200