6-Methoxyflavone [26964-24-9]

MedChem Express

6-Methoxyflavone [26964-24-9]

5

26964-24-9

Research Use Only

99.87

C16H12O3

252.27

6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-kappaB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant alpha1beta2gamma2L and alpha2beta2gamma2L GABAalpha receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases[1][2][3][4][5][6][7][8].

O=C1C=C(C2=CC=CC=C2)OC3=CC=C(OC)C=C13

-20°C,2°C to 8°C

12352200