7-Azido-4-methylcoumarin [95633-27-5] [95633-27-5]

Bioss

7-Azido-4-methylcoumarin [95633-27-5] [95633-27-5]

16

95633-27-5

Research Use Only

Unconjugated

>98%

C10H7N3O2

201.18

7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine beta-synthase (CBS) inhibitors and activators.

CC1=CC(=O)OC2=CC(=CC=C12)N=[N+]=[N-]

-20°C

41115811