7-Chlorokynurenic acid

MedChem Express

7-Chlorokynurenic acid [18000-24-3]

9

18000-24-3

99.86

C10H6ClNO3

223.61

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor ( IC 50 =0.56 microM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a K i of 0.59 microM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery [1] [2] .

O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O

-20°C,2°C to 8°C

12352200