7-Dehydrocholesterol [434-16-2]

Chemodex

7-Dehydrocholesterol [434-16-2]

10

434-16-2

Research Use Only

>95%

C27H44O

384.64

Chemical. CAS: 434-16-2. Formula: C27H44O. MW: 384.64. Synthetic Precursor of cholesterol and vitamin D3. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last step of cholesterol biosynthesis. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS). 7-DHC is used as a biomarker for SLOS screenings. Inhibits human fibroblast sphingomyelinase. Shown to have cytotoxic effects on melanoma cells. In skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3. UV/Vis: lambdamax 271, 282, 293nm. - Precursor of cholesterol and vitamin D3. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last step of cholesterol biosynthesis. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS). 7-DHC is used as a biomarker for SLOS screenings. Inhibits human fibroblast sphingomyelinase. Shown to have cytotoxic effects on melanoma cells. In skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3. UV/Vis: lambdamax 271, 282, 293nm.

[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C

2°C to 8°C,-20°C

12352200