7-Hydroxy methotrexate-d3 (ammonium salt)

MedChem Express

7-Hydroxy methotrexate-d3 (ammonium salt)

5

Research Use Only

C20H22D3N9O6

490.49

7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2][3].

NC1=NC(N)=NC2=C1N=C(C(O)=N2)CN(C3=CC=C(C=C3)C(N[C@H](CCC(O)=O)C(O)=O)=O)C([2H])([2H])[2H].N

12352200