7,4-Dimethoxy-3-hydroxyflavone
HY-174829
Molecular Weight298.29
Product group Chemicals
Overview
- SupplierMedChem Express
- Product Name7,4-Dimethoxy-3-hydroxyflavone
- Delivery Days Customer999
- CertificationResearch Use Only
- Molecular FormulaC17H14O5
- Molecular Weight298.29
- Scientific Description7,4-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 microM. 7,4-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-kappaB, Ca2+/protein kinase C, Akt, ERK and p38. 7,4-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice. 7,4-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time[1][2].
- SMILESCOC1=CC=C(C=C1)C2=C(C(C3=CC=C(C=C3O2)OC)=O)O
- UNSPSC12352200