8-Gingerol

MedChem Express

8-Gingerol [23513-08-8]

10

23513-08-8

Research Use Only

99.82

C19H30O4

322.44

8-Gingerol can be found in the rhizome of ginger ( Z. officinale ) and has oral bioactivity. It activates TRPV1 , with an EC 50 value of 5.0 microM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor ( EGFR ) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis , and regulating autophagy . Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.

CCCCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O

-20°C

12352200