8-hydroxy Efavirenz [205754-33-2]

TargetMol Chemicals

8-hydroxy Efavirenz [205754-33-2]

16

205754-33-2

Chemical

Research Use Only

8-hydroxy Efavirenz

C14H9ClF3NO3

331.68

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 microM.

3 years

Oc1cc(Cl)cc2c1NC(=O)O[C@]2(C#CC1CC1)C(F)(F)F

-20°C

12352200