8-pCPT-2-O-Me-cAMP (sodium) [634207-53-7]

MedChem Express

8-pCPT-2-O-Me-cAMP (sodium) [634207-53-7]

10

634207-53-7

Research Use Only

99.81

C17H16ClN5NaO6PS

507.82

8-pCPT-2-O-Me-cAMP (8-CPT-2-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 microM), but not PKA (EC50 >10 microM). 8-pCPT-2-O-Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic beta-cells in vitro. 8-pCPT-2-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration[1][2][3].

NC1=C2C(N([C@H]3[C@@H]([C@@](O4)([H])[C@](COP4(O[Na])=O)([H])O3)OC)C(SC5=CC=C(Cl)C=C5)=N2)=NC=N1

-20°C

12352200