8(S)-HETE [98462-03-4]

MedChem Express

8(S)-HETE [98462-03-4]

5

98462-03-4

Research Use Only

C20H32O3

320.47

8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 microM. 8(S)-HETE also activates PPARalpha selectively at concentrations as low as 0.3 microM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.

CCCCC/C=C\C/C=C/C=C\[C@H](C/C=C\CCCC(O)=O)O

12352200